ABCA1 inducer 2

• Description:

  ABCA1 inducer 2 is a non-lipotropic ABCA1 inducer. ABCA1 inducer 2 upregulates the expression of ABCA1 by targeting the LXR pathway. ABCA1 inducer 2 can reduce ox-LDL-induced lipid accumulation and thus inhibit foam cell formation. ABCA1 inducer 2 has anti-atherosclerotic potential[1].

• UNSPSC:

  12352005

• Target:

  ATP-binding cassette (ABC) transporters; LXR

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cardiovascular Disease

• Purity:

  98.22

• Smiles:

  O=C1N(CCC2=C3C=CC=C2)C3=NC4=C1C(Br)=CC=C4

• Molecular Formula:

  C16H11BrN2O

• Molecular Weight:

  327.18

• References & Citations:

  [1]Yang C, et al. Synthesis and evaluation of 5, 6-dihydro-8H-isoquinolino[1, 2-b]quinazolin-8-one derivatives as novel non-lipogenic ABCA1 up-regulators with inhibitory effects on macrophage-derived foam cell formation. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2470310.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2451589-46-9]