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ABCB1-IN-3

CAT: 0931-T205499-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205499-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, P-gp
Related Pathways
Membrane transporter/Ion channel, Apoptosis, Neuroscience
Bioactivity
ABCB1-IN-3 (Compound K27) is an orally active ABCB1 inhibitor that induces apoptosis. It binds directly to ABCB1, inhibiting its efflux function and maintaining stable intracellular paclitaxel (PTX) concentrations without affecting the normal expression of ABCB1. In vitro, ABCB1-IN-3 significantly increases ABCB1-mediated multidrug resistance (MDR) sensitivity to PTX, leading to cell cycle arrest and inhibition of cell proliferation. When combined with PTX, ABCB1-IN-3 demonstrates strong antitumor effects in vivo without causing toxicity.
Molecular Formula
C19H16N2O
Molecular Weight
288.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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