PKM2 activator 5

PKM2 activator 5

• CAS Number: 796092-26-7
• UNSPSC Description: PKM2 activator 5 (compound 8) is a PKM2 activator with an AC50 value of 0.316 µM. PKM2 activator 5 has the potential to alter the aberrant metabolism of cancer cells[1].
• Target Antigen: Pyruvate Kinase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pkm2-activator-5.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=S(N1CCN(S(=O)(C2=CC=C(OCCO3)C3=C2)=O)CC1)(C4=CC=CC(F)=C4)=O
• Molecular Weight: 442.48
• References & Citations: [1]Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53(3):1048-55.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported