PKM2 activator 6

PKM2 activator 6

• UNSPSC Description: PKM2 activator 6 (Compound Z10) is a PKM2 activator and PDK1 inhibitor (KD: 121 and 19.6 μM respectively). PKM2 activator 6 induces colorectal cell apoptosis, and inhibits cell proliferation and migration . PKM2 activator 6 inhibits glycolysis. PKM2 activator 6 inhibits proliferation of DLD-1, HCT-8, HT-29, MCF-10A cells (IC50: 10.04, 2.16, 3.57, 66.39 μM)[1].
• Target Antigen: PDK-1; Pyruvate Kinase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pkm2-activator-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(OC)C(CS[C@@H](C(C1=O)=CC(C2=C1C(O)=CC=C2O)=O)C/C=C(C)\C)NC(C3=CC(S(=O)(C)=O)=CC=C3OC)=O
• Molecular Weight: 617.69
• References & Citations: [1]Ma Y, et al. Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment. Bioorg Chem. 2023 Oct;139:106703.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported