PKM2 activator 6

• UNSPSC Description:

  PKM2 activator 6 (Compound Z10) is a PKM2 activator and PDK1 inhibitor (KD: 121 and 19.6 μM respectively). PKM2 activator 6 induces colorectal cell apoptosis, and inhibits cell proliferation and migration . PKM2 activator 6 inhibits glycolysis. PKM2 activator 6 inhibits proliferation of DLD-1, HCT-8, HT-29, MCF-10A cells (IC50: 10.04, 2.16, 3.57, 66.39 μM)[1].

• Target Antigen:

  PDK-1; Pyruvate Kinase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pkm2-activator-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC)C(CS[C@@H](C(C1=O)=CC(C2=C1C(O)=CC=C2O)=O)C/C=C(C)\C)NC(C3=CC(S(=O)(C)=O)=CC=C3OC)=O

• Molecular Weight:

  617.69

• References & Citations:

  [1]Ma Y, et al. Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment. Bioorg Chem. 2023 Oct;139:106703.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported