PKM2 activator 2

• Description:

  PKM2 activator 2 (compound 28) is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 can restore normal glycolytic metabolism in cells[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Pyruvate Kinase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pkm2-activator-2.html

• Purity:

  99.38

• Solubility:

  DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  FC1=C(S(=O)(N2CCN(S(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)CC2)=O)C(F)=CC=C1

• Molecular Formula:

  C20H18F2N2O4S2

• Molecular Weight:

  452.49

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Boxer MB, et al. Evaluation of substituted N, N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53 (3) :1048-55.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1186660-06-9]