ABT-046

• UNSPSC Description:

  ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of both 8 nM against human and mouse DGAT-1[1].

• Target Antigen:

  Acyltransferase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/abt-046.html

• Solubility:

  DMSO : 66.67 mg/mL (ultrasonic)

• Smiles:

  NC1=C(C2=CC=C([C@H]3CC[C@H](CC(O)=O)CC3)C=C2)C=NC4=CC=NN41

• Molecular Weight:

  350.41

• References & Citations:

  [1]Yeh VS, et al. Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of Acyl-CoA: Diacylglycerol acyltransferase 1. J Med Chem. 2012 Feb 23;55(4):1751-1757.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1031336-60-3