ABT-046

• Description :

  ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of both 8 nM against human and mouse DGAT-1[1].

• UNSPSC :

  12352005

• Target :

  Acyltransferase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/abt-046.html

• Purity :

  98.57

• Solubility :

  DMSO : 66.67 mg/mL (ultrasonic)

• Smiles :

  NC1=C(C2=CC=C([C@H]3CC[C@H](CC(O)=O)CC3)C=C2)C=NC4=CC=NN41

• Molecular Formula :

  C20H22N4O2

• Molecular Weight :

  350.41

• References & Citations :

  [1]Yeh VS, et al. Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of Acyl-CoA: Diacylglycerol acyltransferase 1. J Med Chem. 2012 Feb 23;55 (4) :1751-1757.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1031336-60-3]