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ABT-299

CAT: 0804-HY-125309Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125309Size:1 Each
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Description
ABT-299 is a prodrug of a platelet-activating factor (PAF) antagonist that exhibits significant inhibitory activity on PAF-induced β-platelet globulin release in vitro after in vivo administration in humans, an effect that may be partially attributed to the pyridine-N-oxide metabolite.
CAS Number
161395-35-3
UNSPSC
12352005
Target
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/abt-299.html
Smiles
CC(OC[N+]1=CC=CC([C@H]2SCC3=C(C=CN23)C(C4=CN(C5=C4C=CC(C6=CC=C(C=C6)F)=C5)C(N(C)C)=O)=O)=C1)=O.[Cl-]
Molecular Formula
C32H28ClFN4O4S
Molecular Weight
619.11
References & Citations
[1]Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist|[2]Ex vivo inhibition of beta-thromboglobulin release following administration to man of ABT-299, a novel prodrug of a potent platelet activating factor antagonist
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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