PC-046

CAT: 0804-HY-120561Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120561Size:1 Each
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Description
PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice[1].
CAS Number
[1202401-59-9]
UNSPSC
12352005
Target
Apoptosis; IRAK; Pim; Trk Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pc-046.html
Smiles
COC1=CC(C2=C(C=CN=C2)C3=NC=C(O3)C4=CC=C(C=C4)OC)=CC=C1
Molecular Formula
C22H18N2O3
Molecular Weight
358.39
References & Citations
[1]Shaw AY, et al., Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer. J Pharmacol Exp Ther. 2009 Nov;331 (2) :636-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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