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ZS3-046

CAT: 0804-HY-176457Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176457Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model. (Target protein ligand ; CRBN ligase (HY-41547) ; Linker (HY-176469) ; CRBN ligase + Linker (HY-176470) ).
CAS Number
3087879-97-5
UNSPSC
12352005
Target
MDM-2/p53; PROTACs; Small Interfering RNA (siRNA)
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N1C2CCC(NC2=O)=O)C3=C(NCC4CCN(CCCCCCCN5C6=C(C(C(C7=C8NC=C7)=CN(CCC=C)C8=O)=CC(C(N9CCOCC9)=O)=C6)N=C5)CC4)C=CC=C3C1=O
Molecular Formula
C49H57N9O7
Molecular Weight
884.03
References & Citations
[1]Chen L, et al. PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo. Mol Cancer Ther. 2025 May 16:OF1-OF10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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