ABT-002

• Description :

  ABT-002 is a molecular glue degrader targeting GSPT1 and NEK7. ABT-002 is the active metabolite of ABS-752 (HY-W599279) . ABT-002 is promising for research of hepatocellular carcinoma (HCC) [1].

• UNSPSC :

  12352005

• Target :

  Molecular Glues; NEKs

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=C(C(C(O)=O)=C3)F

• Molecular Formula :

  C14H11FN2O5

• Molecular Weight :

  306.25

• References & Citations :

  [1]Glaza P, et al. Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC[J]. bioRxiv, 2025: 2025.06. 25.661504.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2438239-83-7]