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CDK/HDAC-IN-1

CAT: 0804-HY-132914Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-132914Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK/HDAC-IN-1 shows remarkable CDK2/4/6 and HDAC6 inhibitory activity of IC50 = 60.9 ± 2.9, 276 ± 22.3, 27.2 ± 4.2, and 128.6 ± 0.4 nM, respectively.
CAS Number
2762181-73-5
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk-hdac-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(/C1=C2NC3=CC=CC=C3C\2=N/OCCCC(NO)=O)NC4=C1C=CC=C4
Molecular Formula
C20H18N4O4
Molecular Weight
378.38
References & Citations
[1]Cao Z, et al. Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer. J Med Chem. 2021 Oct 28;64 (20) :15280-15296.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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