CDK/HDAC-IN-3

CAT: 0931-T78906-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T78906-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2944087-54-9

Target

HDAC, CDK

Related Pathways

Chromatin/Epigenetic, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

Bioactivity

CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28 nM, and 82.87 nM, respectively, and is applicable in the treatment of acute myeloid leukemia (AML) [1].

Smiles

N(C(=O)C1=C(Cl)C=CC=C1Cl)C=2C(C(NC3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=NNC2

Molecular Formula

C24H18Cl2N6O3

Molecular Weight

509.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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