CDK/HDAC-IN-3

• Target :

  HDAC|||CDK

• Related Pathways :

  Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint

• Bioactivity :

  CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28 nM, and 82.87 nM, respectively, and is applicable in the treatment of acute myeloid leukemia (AML) [1].

• Smiles :

  N(C(=O)C1=C(Cl)C=CC=C1Cl)C=2C(C(NC3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=NNC2

• Molecular Formula :

  C24H18Cl2N6O3

• Molecular Weight :

  509.34

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2944087-54-9