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RIPK1-IN-12

CAT: 0931-T62723-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62723-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2173556-92-6
Target
Necroptosis, RIP kinase
Related Pathways
NF-κB, Apoptosis
Bioactivity
RIPK1-IN-12 is a potent inhibitor of RIPK1, exhibiting an inhibitory effect on necroptosis in human and mouse cells with EC50 values of 1.6 and 2.9 nM, respectively.
Smiles
N(C(=O)C1CC1)C=2SC=3C(N2)=CC=C(C3)C=4C=C(NC(OC5CCCCC5)=O)C(C)=NC4
Molecular Formula
C24H26N4O3S
Molecular Weight
450.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Ripk1-IN-12
CAS Number2173556-92-6
PubChem CID134203893
IUPAC Namecyclohexyl N-[5-[2-(cyclopropanecarbonylamino)-1,3-benzothiazol-6-yl]-2-methyl-3-pyridinyl]carbamate
Molecular FormulaC24H26N4O3S
Molecular Weight450.6
XLogP4.7
Topological Polar Surface Area121
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity684
SMILES
CC1=C(C=C(C=N1)C2=CC3=C(C=C2)N=C(S3)NC(=O)C4CC4)NC(=O)OC5CCCCC5
InChI
InChI=1S/C24H26N4O3S/c1-14-20(27-24(30)31-18-5-3-2-4-6-18)11-17(13-25-14)16-9-10-19-21(12-16)32-23(26-19)28-22(29)15-7-8-15/h9-13,15,18H,2-8H2,1H3,(H,27,30)(H,26,28,29)
InChIKey
NIWSSTRNVNHTMO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ripk1-IN-12
CAS: 2173556-92-6
CID: 134203893
Formula: C24H26N4O3S
MW: 450.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight450.6
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass450.17256188
Monoisotopic Mass450.17256188
Topological Polar Surface Area121 Ų
Heavy Atom Count32
Formal Charge0
Complexity684
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-144277RIPK1-IN-12
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ASD98244-01RIPK1-IN-7
HY-162097RIPK1-IN-20
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HY-175007RIPK1-IN-32

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