RIPK1-IN-33

CAT: 0931-MF-0118793-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118793-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ferroptosis|||RIP kinase
Related Pathways
NF-?B|||Apoptosis
Bioactivity
RIPK1-IN-33 is an orally active RIPK1 inhibitor with excellent blood-brain barrier permeability, exhibiting an IC50 of 0.115 ?M. It demonstrates significant anti-ferroptosis activity, radical scavenging capability (IC50= 123.3 ?M), and anti-lipid peroxidation effects (IC50= 9.72 ?M) . In transient middle cerebral artery occlusion (tMCAO) models, it significantly reduces cerebral infarct volume and improves neurological scores. RIPK1-IN-33 is suitable for ischemic stroke research.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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