RIPK1-IN-33

CAT: 0931-T211713-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211713-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Ferroptosis, RIP kinase

Related Pathways

NF-κB, Apoptosis

Bioactivity

RIPK1-IN-33 is an orally active RIPK1 inhibitor with excellent blood-brain barrier permeability, exhibiting an IC50 of 0.115 μM. It demonstrates significant anti-ferroptosis activity, radical scavenging capability (IC50= 123.3 μM), and anti-lipid peroxidation effects (IC50= 9.72 μM) . In transient middle cerebral artery occlusion (tMCAO) models, it significantly reduces cerebral infarct volume and improves neurological scores. RIPK1-IN-33 is suitable for ischemic stroke research.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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RIPK1-IN-33

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