SNIPER (ABL) -024

CAT: 0804-HY-111861Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-111861Size:1 Each
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Description
SNIPER (ABL) -024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM[1].
CAS Number
[2222355-77-1]
UNSPSC
12352005
Target
Bcr-Abl; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-abl-024.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCOCCOC1=CC(C(C2=CSC([C@H]3N(C([C@H](C4CCCCC4)NC([C@H](C)NC)=O)=O)CCC3)=N2)=O)=CC=C1)C5=CC=CC(C6=NC=NC(NC7=CC=C(OC(F)(F)F)C=C7)=C6)=C5
Molecular Formula
C52H61F3N8O9S
Molecular Weight
1031.15
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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