SNIPER (ABL) -024

• Description:

  SNIPER (ABL) -024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM[1].

• UNSPSC:

  12352005

• Target:

  Bcr-Abl; SNIPERs

• Type:

  Reference compound

• Related Pathways:

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sniper-abl-024.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCCOCCOCCOCCOC1=CC(C(C2=CSC([C@H]3N(C([C@H](C4CCCCC4)NC([C@H](C)NC)=O)=O)CCC3)=N2)=O)=CC=C1)C5=CC=CC(C6=NC=NC(NC7=CC=C(OC(F)(F)F)C=C7)=C6)=C5

• Molecular Formula:

  C52H61F3N8O9S

• Molecular Weight:

  1031.15

• References & Citations:

  [1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2222355-77-1]