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TD-428

CAT: 0013-GTR19227436-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19227436-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TD-428 is a potent and selective BET PROTAC degrader that links JQ1 to a CRBN ligand, inducing efficient BRD4 degradation with a DC50 of 0.32 nM. It is a valuable chemical probe for studying BET protein function in cancer and inflammation research, applicable in both cellular and in vivo models.
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
O=C (NC1=CC (OCCOCCOCCNC2=C3C (N=NN (C (CC4) C (NC4=O) =O) C3=O) =CC=C2) =CC=C1) C[C@H]5C6=NN=C (C) N6C7=C (C (C) =C (C) S7) C (C8=CC=C (Cl) C=C8) =N5
Molecular Formula
C43H43ClN10O7S
Molecular Weight
879.38
Storage Conditions
-20°C
Notes
For research use only.

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