GDC-4379

• Description :

  GDC-4379 is a JAK1 inhibitor that can be used for the research of asthma[1].

• UNSPSC :

  12352005

• Target :

  JAK

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/gdc-4379.html

• Purity :

  98.23

• Solubility :

  DMSO : 31.25 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C2N=CC=CN2N=C1)NC3=CN(CC(N(C)C)=O)N=C3C4=CC(Cl)=CC=C4OC(F)F

• Molecular Formula :

  C21H18ClF2N7O3

• Molecular Weight :

  489.86

• References & Citations :

  [1]Stumpf A, et, al. Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379. Org. Process Res. Dev. 2021, 25, 11, 2537-2550.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2252277-73-7]