GDC-0570

CAT: 0804-HY-171193Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171193Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GDC-0570 is a novel, potent, selective, orally active pan-PIM inhibitor. GDC-0570 demonstrates synergistic antitumor efficacy when combined with Sotorasib (HY-114277) in acquired KRASis-resistant NSCLC[1].
CAS Number
[1586041-58-8]
Product Name Alternative
NB004
UNSPSC
12352005
Target
Pim
Related Pathways
JAK/STAT Signaling
Field of Research
Cancer
Smiles
O=C(C1=CSC(C2=C(C=CC=C2F)F)=N1)NC3=C([C@@H]4CC[C@H]([C@@H](CO4)F)N)N(N=C3)C
Molecular Formula
C20H20F3N5O2S
Molecular Weight
451.47
References & Citations
[1]Fu S, et al. Abstract CT116: Preclinical antitumor activity and first-in-human phase I study of NB004/GDC-0570, a novel pan-PIM kinase inhibitor, in patients with advanced solid tumors[J]. Cancer Research, 2024, 84 (7_Supplement) : CT116-CT116.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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