GDC-0570

• Description :

  GDC-0570 is a novel, potent, selective, orally active pan-PIM inhibitor. GDC-0570 demonstrates synergistic antitumor efficacy when combined with Sotorasib (HY-114277) in acquired KRASis-resistant NSCLC[1].

• Product Name Alternative :

  NB004

• UNSPSC :

  12352005

• Target :

  Pim

• Related Pathways :

  JAK/STAT Signaling

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=CSC(C2=C(C=CC=C2F)F)=N1)NC3=C([C@@H]4CC[C@H]([C@@H](CO4)F)N)N(N=C3)C

• Molecular Formula :

  C20H20F3N5O2S

• Molecular Weight :

  451.47

• References & Citations :

  [1]Fu S, et al. Abstract CT116: Preclinical antitumor activity and first-in-human phase I study of NB004/GDC-0570, a novel pan-PIM kinase inhibitor, in patients with advanced solid tumors[J]. Cancer Research, 2024, 84 (7_Supplement) : CT116-CT116.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1586041-58-8]