GDC-2992

CAT: 0804-HY-156751A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-156751A-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GDC-2992 (Compound 28A) is an orally bioavailable androgen receptor (AR) PROTAC degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. GDC-2992 can be used for prostatic cancer study. (Structure Note: Pink: target protein ligand (HY-130845) ; Blue: E3 ligase ligand (HY-W1003189A) ; Black: linker (HY-169975) ; E3 ligase ligand +linker (HY-169976A) ) [1].
CAS Number
[2753651-10-2]
Product Name Alternative
RO7656594
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.38
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(N4CCC(CN5CCN(C6=CC(C=NN([C@@H]7C(NC(CC7)=O)=O)C8=O)=C8C=C6)CC5)CC4)C=C3)=O)C2(C)C)C=C1Cl
Molecular Formula
C45H51ClN8O5
Molecular Weight
819.39
References & Citations
[1]HF Lu, et al. Phthalazinone compound, and preparation method therefor and medical use thereof. WO2021249534A1.|[2]Ciara Metcalfe, et al. Abstract ND02: GDC-2992: A heterobifunctional Androgen Receptor (AR) antagonist and degrader for the treatment of AR wild-type and mutant prostate cancer. Cancer Res (2025) 85 (8_Supplement_2) : ND02.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Related Products

CatalogName
HY-101272-01GDC-0326
HY-160851-01GDC-3280
HY-19926-01GDC-0425
HY-171193GDC-0570
HY-50864-01GDC-0879
HY-15427-01GDC-0834
HY-148258-01GDC-2394
HY-111484-01GDC-0927
HY-15248-01GDC-0349
HY-139837-01GDC-4379

Alternative Products

CatalogName
MF-0097836-01GDC-2992
SIH-496-5MGBIBW 2992
abx283009-01BIBW 2992 (Afatinib)
60B981GDC
MBS131624-01GDC-0326 ?GDC0326? GDC 0326?
TBI4510-50MGBIBW 2992 (Afatinib), EGFR and HER2 inhibitor
MBS3606501-01GDC-0879
MBS3601585-01GDC-0084
MBS3607157-01GDC-0623
MBS384746-01GDC-0349

Popular Products