GDC-0326

• Description:

  GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM.

• UNSPSC:

  12352005

• Target:

  PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GDC-0326.html

• Concentration:

  10mM

• Purity:

  99.92

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

• Molecular Formula:

  C19H22N6O3

• Molecular Weight:

  382.42

• References & Citations:

  [1]Heffron TP, et al. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S) -2- ((2- (1-Isopropyl-1H-1,2,4-triazol-5-yl) -5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl) oxy) propanamide (GDC-0326) . J Med Chem. 2016 Feb 11;59 (3) :985-1002.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

• CAS Number:

  [1282514-88-8]