GDC-0349

• Description:

  GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

• UNSPSC:

  12352005

• Target:

  Autophagy; mTOR

• Type:

  Reference compound

• Related Pathways:

  Autophagy; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gdc-0349.html

• Purity:

  99.81

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CCN(C4COC4)C3)C(N5[C@@H](C)COCC5)=N2

• Molecular Formula:

  C24H32N6O3

• Molecular Weight:

  452.55

• References & Citations:

  [1]Pei Z, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4 (1) :103-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  MTOR; mTORC1; mTORC2

• CAS Number:

  [1207360-89-1]