GDC-0349

CAT: 0804-HY-15248-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15248-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.
CAS Number
[1207360-89-1]
UNSPSC
12352005
Target
Autophagy; mTOR
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gdc-0349.html
Purity
99.81
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CCN(C4COC4)C3)C(N5[C@@H](C)COCC5)=N2
Molecular Formula
C24H32N6O3
Molecular Weight
452.55
References & Citations
[1]Pei Z, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4 (1) :103-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
MTOR; mTORC1; mTORC2

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Alternative Products

CatalogName
MBS3607187-01GDC-0349
MBS132459-01GDC-0349, RG7603
A11443-10GDC-0349 10mg
A11443-25GDC-0349 25mg
A11443-50GDC-0349 50mg
A11443-100GDC-0349 100mg
A11443-2GDC-0349 2mg
A11443-5GDC-0349 5mg
bs-60110C-01GDC-0349 --- mTOR Inhibitor
A11443-10mM-DGDC-0349 10mM * 1mL in DMSO

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