GDC-0879

• Description:

  GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H228, H302, H317, H319, H341, H351

• Target:

  Raf

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GDC-0879.html

• Purity:

  99.92

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O/N=C1C(C=CC(C2=CN(CCO)N=C2C3=CC=NC=C3)=C4)=C4CC/1

• Molecular Formula:

  C19H18N4O2

• Molecular Weight:

  334.37

• Precautions:

  H228, H302, H317, H319, H341, H351

• References & Citations:

  [1]Hansen JD, et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 15;18 (16) :4692-5.|[2]Wong H, et al. Pharmacodynamics of 2-[4-[ (1E) -1- (hydroxyimino) -2,3-dihydro-1H-inden-5-yl]-3- (pyridine-4-yl) -1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther. 2009 Apr;329 (1) :360-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  B-Raf

• CAS Number:

  905281-76-7