GDC-0134

CAT: 0804-HY-148629-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-148629-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GDC-0134 is a potent, selective, orally active, brain-penetrant dual leucine zipper kinase (DLK) inhibitor. GDC-0134 blocks DLK activity in cellular assays and in animal models of neuronal injury. GDC-0134 can be used for the study of amyotrophic lateral sclerosis (ALS) [1].

CAS Number

1637394-01-4

UNSPSC

12352005

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gdc-0134.html

Purity

99.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=C(C=C(C=N1)C2=NC(N3CC(F)(CC3)F)=NC(N4C[C@H]5OC[C@@H]4C5)=C2)OC(F)F

Molecular Formula

C19H20F4N6O2

Molecular Weight

440.39

References & Citations

[1]Jonathan S Katz, et al. A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS. Ann Clin Transl Neurol. 2022 Jan;9 (1) :50-66.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

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GDC-0134

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