Thalidomide-5-methyl

• Description:

  Thalidomide-5-methyl is the Thalidomide (HY-14658) -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Thalidomide-5-methyl can be used to synthesize PROTAC[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H312, H361

• Target:

  Apoptosis; Autophagy; Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-5-methyl.html

• Purity:

  99.87

• Solubility:

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1NC (C (CC1) N2C (C3=CC=C (C) C=C3C2=O) =O) =O

• Molecular Formula:

  C14H12N2O4

• Molecular Weight:

  272.26

• Precautions:

  H301, H312, H361

• References & Citations:

  [1]George W. Muller, et al. Substituted 2- (2,6 dioxo-3-fluoropiperidin-3-yl) -isoindolines and method of reducing TNFα levels. Patent US5874448A.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  40313-92-6