Thalidomide-5-methyl

• Description :

  Thalidomide-5-methyl is the Thalidomide (HY-14658) -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Thalidomide-5-methyl can be used to synthesize PROTAC[1].

• CAS Number :

  [40313-92-6]

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H312, H361

• Target :

  Apoptosis; Autophagy; Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/thalidomide-5-methyl.html

• Purity :

  99.87

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1NC(C(CC1)N2C(C3=CC=C(C)C=C3C2=O)=O)=O

• Molecular Formula :

  C14H12N2O4

• Molecular Weight :

  272.26

• Precautions :

  H301, H312, H361

• References & Citations :

  [1]George W. Muller, et al. Substituted 2- (2,6 dioxo-3-fluoropiperidin-3-yl) -isoindolines and method of reducing TNFα levels. Patent US5874448A.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon