Thalidomide-5-COOH

• UNSPSC Description:

  Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].

• Target Antigen:

  Apoptosis; Autophagy; Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-5-cooh.html

• Smiles:

  O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)O

• Molecular Weight:

  302.242

• References & Citations:

  [1]Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  1216805-11-6