Thalidomide-5-OH

• Description :

  Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

• CAS Number :

  [64567-60-8]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Autophagy; Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/thalidomide-5-oh.html

• Purity :

  99.65

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3)=O

• Molecular Formula :

  C13H10N2O5

• Molecular Weight :

  274.23

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25 (5) :597-604.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon