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Thalidomide-5-OH

CAT: 0804-HY-23095-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-23095-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1].
CAS Number
64567-60-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-oh.html
Purity
99.65
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(O)=C3)=O
Molecular Formula
C13H10N2O5
Molecular Weight
274.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25 (5) :597-604.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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