Thalidomide-5-carbaldehyde

• Target:

  Ligand for E3 Ligase

• Related Pathways:

  PROTAC

• Bioactivity:

  Thalidomide-5-carbaldehyde is an aldehyde-containing analogue of Thalidomide. Thalidomide recruits E3 ligase for ubiquitination, leading to proteolysis of target proteins. The aldehyde group exhibits high reactivity towards amine nucleophiles through reactions such as reductive amination.

• Smiles:

  O=CC1=CC=C2C(=O)N(C(=O)C2=C1)C3C(=O)NC(=O)CC3

• Molecular Formula:

  C14H10N2O5

• Molecular Weight:

  286.24

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1447701-63-4