Thalidomide 5-fluoride

• Description:

  Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1) . PROTAC IRAK4 degrader-1 caused 20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H361

• Target:

  Apoptosis; Autophagy; Ligands for E3 Ligase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-5-fluoride.html

• Purity:

  99.96

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(F)=C3)=O

• Molecular Formula:

  C13H9FN2O4

• Molecular Weight:

  276.22

• Precautions:

  H301, H361

• References & Citations:

  [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]|[2]Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  [835616-61-0]