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Thalidomide 5-fluoride

CAT: 0804-HY-W087383-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W087383-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1) . PROTAC IRAK4 degrader-1 caused 20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively[1][2].
CAS Number
835616-61-0
UNSPSC
12352005
Hazard Statement
H301, H361
Target
Apoptosis; Autophagy; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-fluoride.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(F)=C3)=O
Molecular Formula
C13H9FN2O4
Molecular Weight
276.22
Precautions
H301, H361
References & Citations
[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]|[2]Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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