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Thalidomide-5-propargyl

CAT: 0804-HY-W457950-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W457950-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide-5-propargyl is a propargyl-modified Thalidomide , that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].
CAS Number
2226303-74-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-propargyl.html
Purity
95.87
Solubility
10 mM in DMSO
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(OCC#C)=C3)=O
Molecular Formula
C16H12N2O5
Molecular Weight
312.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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