hCAIX/XII-IN-13

hCAIX/XII-IN-13

• UNSPSC Description: hCAIX/XII-IN-13 is an inhibitor of human carbonic anhydrases (hCA). hCAIX/XII-IN-13 shows good inhibitory activity against the tumor-related CA subtypes IX and XII, with Ki values of 0.08 µM and 0.06 µM, respectively. Under hypoxic conditions, hCAIX/XII-IN-13 can restore the cytotoxicity of Doxorubicin (HY-15142A) on MCF-7 cells, increasing G2/M phase cell cycle arrest and apoptosis[1].
• Target Antigen: Apoptosis
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hcaix-xii-in-13.html
• Smiles: O=C(C(C1=NC(N=C(N(C2=CC=C(S(N)(=O)=O)C=C2)N=C3C(C)=O)N3C4=O)=C4C=C1)=C5)OC6=C5C=CC=C6
• Molecular Weight: 528.50
• References & Citations: [1]Abdelaal HI, et al. Mitigating the resistance of MCF-7 cancer cells to Doxorubicin under hypoxic conditions with novel coumarin based carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2024 Nov;152:107759.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported