hCAIX/XII-IN-2

hCAIX/XII-IN-2

• CAS Number: 2414629-82-4
• UNSPSC Description: hCAIX/XII-IN-2 (compound 6a) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 30.0, 3.6 nM for hCAI, hCAII, hCAIX and hCAXII, respectively[1].
• Target Antigen: Carbonic Anhydrase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hcaix-xii-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C=C(C)C2=C(O1)C=C(OCC3=NOC(C4=CC=CC=C4)=N3)C=C2
• Molecular Weight: 334.33
• References & Citations: [1]Thacker PS, et al. Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 May;98:103739.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported