hCAIX/XII-IN-1
CAT:
804-HY-146988
Size:
Inquire
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
hCAIX/XII-IN-1
- CAS Number: 3033040-76-2
- UNSPSC Description: hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the KI values of 0.48 μM and 0.83 μM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells[1].
- Target Antigen: Apoptosis; Carbonic Anhydrase
- Type: Reference compound
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/hcaix-xii-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=CC2=C(OC1=O)C=CC=C2)CN3C(S/C(C3=O)=C\C4=CC=CS4)=O
- Molecular Weight: 397.42
- References & Citations: [1]Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37(1):531-541.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported