hCAIX/XII-IN-1

hCAIX/XII-IN-1

• CAS Number: 3033040-76-2
• UNSPSC Description: hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the KI values of 0.48 μM and 0.83 μM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells[1].
• Target Antigen: Apoptosis; Carbonic Anhydrase
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hcaix-xii-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC2=C(OC1=O)C=CC=C2)CN3C(S/C(C3=O)=C\C4=CC=CS4)=O
• Molecular Weight: 397.42
• References & Citations: [1]Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37(1):531-541.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported