hCAIX/XII-IN-7

• UNSPSC Description:

  hCAIX/XII-IN-7 (compound 3e) is a potent hCA IX and XII inhibitor with Kis of 3.2 nM, 9.2 nM, 503.7 nM and 59 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. hCAIX/XII-IN-7 has the potential for hypoxic tumors research[1].

• Target Antigen:

  Carbonic Anhydrase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hcaix-xii-in-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=CC=C(N(N=C/2C)C(C2=N\NC(C=C3)=CC=C3S(=O)(N)=O)=O)C=C1

• Molecular Weight:

  382.40

• References & Citations:

  [1]Suleyman Akocak, et al. Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorg Med Chem Lett. 2023 Oct 15:95:129479.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported