hCAIX/XII-IN-5
CAT:
804-HY-150695
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
hCAIX/XII-IN-5
- CAS Number: 2421127-99-1
- UNSPSC Description: hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (Ki=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis[1].
- Target Antigen: Apoptosis; Carbonic Anhydrase
- Type: Reference compound
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/hcaix-xii-in-5.html
- Solubility: 10 mM in DMSO
- Smiles: O=C1C(C(/C=C/NC2=CC=CC=C2)=O)=CC3=C(O1)C=CC=C3
- Molecular Weight: 291.30
- References & Citations: [1]Hany S Ibrahim Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity. Bioorg Chem. 2022 Sep;126:105888.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported