hCAIX/XII-IN-8

• UNSPSC Description:

  hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].

• Target Antigen:

  Carbonic Anhydrase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hcaix-xii-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N(N=C/1C)C2=CC=C(Cl)C=C2Cl)C1=N\NC(C=C3)=CC=C3S(=O)(N)=O

• Molecular Weight:

  426.28

• References & Citations:

  [1]Akocak S, et al. Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorg Med Chem Lett. 2023 Oct 15;95:129479.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  59994-64-8