Products for Research Use Only
RegisterLogin

P 22077

CAT: 0804-HY-13865-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13865-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. P 22077 also inhibits USP47 with an EC50 of 8.74 μM.
CAS Number
1247819-59-5
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-22077.html
Purity
98.07
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O
Molecular Formula
C12H7F2NO3S2
Molecular Weight
315.32
Precautions
H302, H410
References & Citations
[1]Altun M, et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem Biol. 2011 Nov 23;18 (11) :1401-12.|[2]Fan YH, et al. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis. 2013 Oct 17;4:e867.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-157091Uridine, 5'- (P, P', P'', P''-tetrahydrogen imidotriphosphate)
HY-157093Cytidine, 5′- (P, P′, P′′, P′′-tetrahydrogen imidotriphosphate)
HY-B1984-01P, p'-DDD
HY-B1986-01P, p'-DDE
HY-W750297P, p'-DDD-13C12
HY-B1984R-01P, p'-DDD (Standard)
HY-B1984S-01P, p'-DDD-d8
HY-B1986R-01P, p'-DDE (Standard)
HY-B1986S-01P, p'-DDE-d8
HY-W753141P, p'-DDE-13C12

Alternative Products

CatalogName
256138-01P 22077
A12933-50P 22077 50mg
A12933-25P 22077 25mg
A12933-100P 22077 100mg
A12933-10P 22077 10mg
A12933-5P 22077 5mg
A12933-2P 22077 2mg
A12933-10mM-DP 22077 10mM * 1mL in DMSO
2301-25USP7/USP47 Inhibitor, P 22077

Popular Products