P, p'-DDD-d8

P, p'-DDD-d8 is the deuterium labeled p, p'-DDD[1]. p, p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p, p'-DDT. p, p'-DDD is an agonist at estrogen receptor α (ERα) and ERβ. p, p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p, p'-DDD stimulates cell proliferation in SKBR3 cells. p, p'-DDD activates the AP-1 transcription factor. p, p'-DDD decreases sleep times of barbiturates and steroids in rats[1][2][3][4][5].

93952-20-6

4,4'-DDD-d8; p, p'-Dichlorodiphenyl dichloroethane-d8

12352005

Apoptosis; Drug Metabolite; Insecticide; Necroptosis

Isotope-Labeled Compounds

Apoptosis; Metabolic Enzyme/Protease; Others

Metabolism-protein/nucleotide metabolism

Cancer; Infection; Neurological Disease

10 mM in DMSO

ClC(Cl)C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl

C14H2D8Cl4

328.09

[1]Gerić M, et al. Cytogenetic status of human lymphocytes after exposure to low concentrations of p, p'-DDT, and its metabolites (p, p'-DDE, and p, p'-DDD) in vitro. Chemosphere. 2012 Jun;87 (11) :1288-94. |[2]Wang L, et al. Binding and Activation of Estrogen-Related Receptor γ: A Novel Molecular Mechanism for the Estrogenic Disruption Effects of DDT and Its Metabolites. Environ Sci Technol. 2022 Sep 6;56 (17) :12358-12367.|[3]Frigo DE, et al. DDT and its metabolites alter gene expression in human uterine cell lines through estrogen receptor-independent mechanisms. Environ Health Perspect. 2002 Dec;110 (12) :1239-45. |[4]Azarnoff DL, et al. The effect of DDD on barbiturate and steroid-induced hypnosis in the dog and rat. Biochem Pharmacol. 1966 Dec;15 (12) :1985-93. |[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Room temperature

Isotope-Labeled Compounds