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P, p'-DDE-d8

CAT: 0804-HY-B1986S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1986S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P, p'-DDE-d8 is the deuterium labeled p, p'-DDE[1]. p, p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].
CAS Number
93952-19-3
Product Name Alternative
4,4'-DDE-d8; p, p'-Dichlorodiphenyldichloroethylene-d8
UNSPSC
12352005
Target
Androgen Receptor; Drug Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Purity
99
Solubility
10 mM in DMSO
Smiles
Cl/C(Cl)=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)/C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl
Molecular Formula
C14D8Cl4
Molecular Weight
326.07
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kelce WR, et al. Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375 (6532) :581-585.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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