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P, p'-DDE

CAT: 0804-HY-B1986-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1986-01Size:100 mg
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Description
P, p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p, p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p, p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p, p'-DDE may be a risk factor for type 2 diabetes in women[1][2].
CAS Number
72-55-9
Product Name Alternative
4,4'-DDE; p, p'-Dichlorodiphenyldichloroethylene
UNSPSC
12352005
Hazard Statement
H301, H351, H372, H410
Target
Androgen Receptor; Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/p-p-dde.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Cl/C(Cl)=C(C1=CC=C(Cl)C=C1)/C2=CC=C(Cl)C=C2
Molecular Formula
C14H8Cl4
Molecular Weight
318.03
Precautions
H301, H351, H372, H410
References & Citations
[1]Kelce WR, et al. Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375 (6532) :581-585.|[2]Rignell-Hydbom A, et al. Exposure to p, p'-DDE: a risk factor for type 2 diabetes. PLoS One. 2009 Oct 19;4 (10) :e7503.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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