P, p'-DDE

• Description :

  P, p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p, p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p, p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p, p'-DDE may be a risk factor for type 2 diabetes in women[1][2].

• Product Name Alternative :

  4,4'-DDE; p, p'-Dichlorodiphenyldichloroethylene

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H351, H372, H410

• Target :

  Androgen Receptor; Drug Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/p-p-dde.html

• Concentration :

  10mM

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  Cl/C(Cl)=C(C1=CC=C(Cl)C=C1)/C2=CC=C(Cl)C=C2

• Molecular Formula :

  C14H8Cl4

• Molecular Weight :

  318.03

• Precautions :

  H301, H351, H372, H410

• References & Citations :

  [1]Kelce WR, et al. Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375 (6532) :581-585.|[2]Rignell-Hydbom A, et al. Exposure to p, p'-DDE: a risk factor for type 2 diabetes. PLoS One. 2009 Oct 19;4 (10) :e7503.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [72-55-9]