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P, p'-DDD

CAT: 0804-HY-B1984-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1984-01Size:100 mg
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Description
P, p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p, p'-DDT. p, p'-DDD is an agonist at estrogen receptor α (ERα) and ERβ. p, p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p, p'-DDD stimulates cell proliferation in SKBR3 cells. p, p'-DDD activates the AP-1 transcription factor. p, p'-DDD decreases sleep times of barbiturates and steroids in rats[1][2][3][4].
CAS Number
72-54-8
Product Name Alternative
4,4'-DDD; p, p'-Dichlorodiphenyl dichloroethane
UNSPSC
12352005
Hazard Statement
H301, H312, H351, H410
Target
Apoptosis; Drug Metabolite; Insecticide; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p-p-ddd.html
Concentration
10mM
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(Cl)C(C1=CC=C(Cl)C=C1)C2=CC=C(Cl)C=C2
Molecular Formula
C14H10Cl4
Molecular Weight
320.04
Precautions
H301, H312, H351, H410
References & Citations
[1]Gerić M, et al. Cytogenetic status of human lymphocytes after exposure to low concentrations of p, p'-DDT, and its metabolites (p, p'-DDE, and p, p'-DDD) in vitro. Chemosphere. 2012 Jun;87 (11) :1288-94.|[2]Wang L, et al. Binding and Activation of Estrogen-Related Receptor γ: A Novel Molecular Mechanism for the Estrogenic Disruption Effects of DDT and Its Metabolites. Environ Sci Technol. 2022 Sep 6;56 (17) :12358-12367. |[3]Frigo DE, et al. DDT and its metabolites alter gene expression in human uterine cell lines through estrogen receptor-independent mechanisms. Environ Health Perspect. 2002 Dec;110 (12) :1239-45.|[4]Azarnoff DL, et al. The effect of DDD on barbiturate and steroid-induced hypnosis in the dog and rat. Biochem Pharmacol. 1966 Dec;15 (12) :1985-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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