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P, p'-DDE-13C12

CAT: 0804-HY-W753141Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W753141Size:1 Each
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Description
P, p'-DDE-13C12 is 13C labeled p, p'-DDE. p, p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[1][2].
CAS Number
201612-50-2
Product Name Alternative
4,4'-DDE-13C12; p, p'-Dichlorodiphenyldichloroethylene-13C12
UNSPSC
12352005
Target
Androgen Receptor; Drug Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/p-p-dde-13c12.html
Smiles
C(=C(Cl)Cl)([13C]1=[13CH][13CH]=[13C](Cl)[13CH]=[13CH]1)[13C]2=[13CH][13CH]=[13C](Cl)[13CH]=[13CH]2
Molecular Formula
C2 13C12H8Cl4
Molecular Weight
329.94
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kelce WR, et al. Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375 (6532) :581-585.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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