p,p'-DDE-13C12
CAT:
804-HY-W753141
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
p,p'-DDE-13C12
- CAS Number: 201612-50-2
- UNSPSC Description: p,p'-DDE-13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[1][2].
- Target Antigen: Androgen Receptor; Drug Metabolite; Isotope-Labeled Compounds
- Type: Isotope-Labeled Compounds
- Related Pathways: Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor
- Field of Research: Endocrinology
- Assay Protocol: https://www.medchemexpress.com/p-p-dde-13c12.html
- Smiles: C(=C(Cl)Cl)([13C]1=[13CH][13CH]=[13C](Cl)[13CH]=[13CH]1)[13C]2=[13CH][13CH]=[13C](Cl)[13CH]=[13CH]2
- Molecular Weight: 329.94
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kelce WR, et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported