p,p'-DDE-13C12

• UNSPSC Description:

  p,p'-DDE-13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[1][2].

• Target Antigen:

  Androgen Receptor; Drug Metabolite; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease;Others;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/p-p-dde-13c12.html

• Smiles:

  C(=C(Cl)Cl)([13C]1=[13CH][13CH]=[13C](Cl)[13CH]=[13CH]1)[13C]2=[13CH][13CH]=[13C](Cl)[13CH]=[13CH]2

• Molecular Weight:

  329.94

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kelce WR, et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  201612-50-2