ITD-1

• Description :

  ITD-1 is the first selective TGFβ receptor inhibitor with an IC50 of 460 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  TGF-β Receptor

• Type :

  Reference compound

• Related Pathways :

  TGF-beta/Smad

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ITD-1.html

• Concentration :

  10mM

• Purity :

  99.41

• Solubility :

  DMSO : 28 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C(C4=CC=CC=C4)C=C3)OCC

• Molecular Formula :

  C27H29NO3

• Molecular Weight :

  415.52

• Precautions :

  H302

• References & Citations :

  [1]Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11 (2) :242-52.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1099644-42-4]