ITD-1

• Description:

  ITD-1 is the first selective TGFβ receptor inhibitor with an IC50 of 460 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ITD-1.html

• Concentration:

  10mM

• Purity:

  99.41

• Solubility:

  DMSO : 28 mg/mL (ultrasonic; warming)

• Smiles:

  O=C (C1=C (C) NC2=C (C (CC (C) (C) C2) =O) C1C3=CC=C (C4=CC=CC=C4) C=C3) OCC

• Molecular Formula:

  C27H29NO3

• Molecular Weight:

  415.52

• Precautions:

  H302

• References & Citations:

  [1]Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11 (2) :242-52.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1099644-42-4