ITD-1

• UNSPSC Description:

  ITD-1 is the first selective TGFβ receptor inhibitor with an IC50 of 460 nM.

• Target Antigen:

  TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  TGF-beta/Smad

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ITD-1.html

• Purity:

  99.41

• Solubility:

  DMSO : 28 mg/mL (ultrasonic;warming)

• Smiles:

  O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C(C4=CC=CC=C4)C=C3)OCC

• Molecular Weight:

  415.52

• References & Citations:

  [1]Willems E, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11(2):242-52.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1099644-42-4