FLT3/ITD-IN-1
CAT:
804-HY-144709
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FLT3/ITD-IN-1
- UNSPSC Description: FLT3/ITD-IN-1 (Compound 1) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 38.2 nM and 144.1 nM against FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-1 displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].
- Target Antigen: FLT3
- Type: Reference compound
- Related Pathways: Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/flt3-itd-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: COC1=CC=CC=C1NC(C2=C3N=C(C=CN3N=C2)N[C@@H]4CCCNC4)=O
- Molecular Weight: 366.42
- References & Citations: [1]Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported