FLT3/ITD-IN-1

• UNSPSC Description:

  FLT3/ITD-IN-1 (Compound 1) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 38.2 nM and 144.1 nM against FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-1 displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

• Target Antigen:

  FLT3

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-itd-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=CC=C1NC(C2=C3N=C(C=CN3N=C2)N[C@@H]4CCCNC4)=O

• Molecular Weight:

  366.42

• References & Citations:

  [1]Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported