PDGFRα/FLT3-ITD-IN-1

PDGFRα/FLT3-ITD-IN-1

• CAS Number: 2761259-05-4
• UNSPSC Description: PDGFRα/FLT3-ITD-IN-1 (Compound 12d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of more than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1].
• Target Antigen: FLT3; PDGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pdgfrα-flt3-itd-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: NCCCCNC(C1=CC=C(C=C1)NC2=NC(N[C@@H]3CC[C@H](CC3)N)=NC4=C2N=CN4C5CCCC5)=O
• Molecular Weight: 505.66
• References & Citations: [1] Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported