FLT3/ITD-IN-4

FLT3/ITD-IN-4

• CAS Number: 2278278-04-7
• UNSPSC Description: FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].
• Target Antigen: CDK; FLT3; MAP4K; RET
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-itd-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)(C1=CC(NC(NC2=CC=C3OC(C(C4=CC5=C(N4)C=CC(O)=C5)=O)=CC3=C2)=O)=NO1)C
• Molecular Weight: 458.47
• References & Citations: [1]Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported