FLT3-ITD/D835Y-IN-1
CAT:
804-HY-161323
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FLT3-ITD/D835Y-IN-1
- UNSPSC Description: FLT3-ITD/D835Y-IN-1 (Compound 1) is a FLT3-ITD and BCR-ABL inhibitor. FLT3-ITD/D835Y-IN-1 mediates proapoptosis by inhibiting the FLT3 and BCR-ABL pathways, as well as other possible targets. FLT3-ITD/D835Y-IN-1 can be used in the study of acute myeloid leukemia (AML)[1].
- Target Antigen: Apoptosis; Bcr-Abl; FLT3
- Type: Reference compound
- Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/flt3-itd-d835y-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: COC1=CC=CC(NC2=CC=CC(C3=CN=C4N3C=CC(C5=CN(C)N=C5)=C4)=N2)=C1
- Molecular Weight: 396.44
- References & Citations: [1]Wang X, et al. N-(3-Methoxyphenyl)-6-(7-(1-methyl-1H-pyrazol-4-yl) imidazo [1, 2-a] pyridin-3-yl) pyridin-2-amine is an inhibitor of the FLT3-ITD and BCR-ABL pathways, and potently inhibits FLT3-ITD/D835Y and FLT3-ITD/F691L secondary mutants. Bioorganic Chemistry, 2024, 143: 106966.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported