FLT3-ITD/D835Y-IN-1

• UNSPSC Description:

  FLT3-ITD/D835Y-IN-1 (Compound 1) is a FLT3-ITD and BCR-ABL inhibitor. FLT3-ITD/D835Y-IN-1 mediates proapoptosis by inhibiting the FLT3 and BCR-ABL pathways, as well as other possible targets. FLT3-ITD/D835Y-IN-1 can be used in the study of acute myeloid leukemia (AML)[1].

• Target Antigen:

  Apoptosis; Bcr-Abl; FLT3

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-itd-d835y-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=CC(NC2=CC=CC(C3=CN=C4N3C=CC(C5=CN(C)N=C5)=C4)=N2)=C1

• Molecular Weight:

  396.44

• References & Citations:

  [1]Wang X, et al. N-(3-Methoxyphenyl)-6-(7-(1-methyl-1H-pyrazol-4-yl) imidazo [1, 2-a] pyridin-3-yl) pyridin-2-amine is an inhibitor of the FLT3-ITD and BCR-ABL pathways, and potently inhibits FLT3-ITD/D835Y and FLT3-ITD/F691L secondary mutants. Bioorganic Chemistry, 2024, 143: 106966.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported