FLT3-ITD-IN-2

FLT3-ITD-IN-2

• UNSPSC Description: FLT3-ITD-IN-2 (Compound A1) is an inhibitor for FLT3-ITD kinase with an IC50 of 2.12 nM. FLT3-ITD-IN-2 inhibits the proliferation of FLT3-dependent human AML cell line MOLM-13 with an IC50 of 25.65 nM. FLT3-ITD-IN-2 exhibits antitumor efficacy against acute myeloid leukemia[1].
• Target Antigen: FLT3
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-itd-in-2-7.html
• Smiles: O=C([C@@]12[C@@H]3[C@@H]4[C@H]1[C@H]5[C@]4(C(OC)=O)[C@H]3[C@@H]25)N6CCN(C7CCN(C8=C(OC)C=C(NC9=C(C(N)=O)N=C(CC)C(NC%10CCOCC%10)=N9)C=C8)CC7)CC6
• Molecular Weight: 726.86
• References & Citations: [1]Chu D, et al., Identification of inhibitors targeting the FLT3-ITD mutation through 4D-QSAR, in vitro, and in silico. Eur J Med Chem. 2025 Jan 15;282:117089.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported