FLT3-ITD-IN-2

• UNSPSC Description:

  FLT3-ITD-IN-2 (Compound A1) is an inhibitor for FLT3-ITD kinase with an IC50 of 2.12 nM. FLT3-ITD-IN-2 inhibits the proliferation of FLT3-dependent human AML cell line MOLM-13 with an IC50 of 25.65 nM. FLT3-ITD-IN-2 exhibits antitumor efficacy against acute myeloid leukemia[1].

• Target Antigen:

  FLT3

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-itd-in-2-7.html

• Smiles:

  O=C([C@@]12[C@@H]3[C@@H]4[C@H]1[C@H]5[C@]4(C(OC)=O)[C@H]3[C@@H]25)N6CCN(C7CCN(C8=C(OC)C=C(NC9=C(C(N)=O)N=C(CC)C(NC%10CCOCC%10)=N9)C=C8)CC7)CC6

• Molecular Weight:

  726.86

• References & Citations:

  [1]Chu D, et al., Identification of inhibitors targeting the FLT3-ITD mutation through 4D-QSAR, in vitro, and in silico. Eur J Med Chem. 2025 Jan 15;282:117089.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported