FLT3/ITD-IN-3

• CAS Number:

  2489446-47-9

• UNSPSC Description:

  FLT3/ITD-IN-3 (Compound 19) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 0.9 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-3 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

• Target Antigen:

  FLT3

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/flt3-itd-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C2N=C(C=CN2N=C1)N[C@@H]3CCCNC3)NC4=CC=C(C=C4Cl)N5CCOCC5

• Molecular Weight:

  455.94

• References & Citations:

  [1]Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported