PRMT5-IN-1

CAT: 0804-HY-126256Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-126256Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PRMT5 IN-1, a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions[1].
CAS Number
[2366149-83-7]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-1.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@@H]([C@@H](C2=CC=C(Cl)C=C2)O)O[C@@H](N3C=CC4=C3N=CN5C4=NCC5O)[C@@H]1O
Molecular Formula
C19H19ClN4O5
Molecular Weight
418.83
References & Citations
[1]Lin H, et, al. Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. ACS Med Chem Lett. 2019 May 22;10 (7) :1033-1038.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5

Related Products

CatalogName
HY-163799PRMT5-MTA-IN-1
HY-163434PRMT5/EGFR-IN-1
HY-153422-01PRMT5-IN-29
HY-163589PRMT5-IN-40
HY-163588-01PRMT5-IN-39
HY-132937PRMT5-IN-9
HY-163592PRMT5-IN-43
HY-111213PRMT5-IN-20
HY-169708-01PRMT5-IN-49
HY-170603PRMT5-targeted fluorescent ligand-1

Alternative Products

CatalogName
T12541-01PRMT5-IN-1
T210406-01PRMT5-MTA-IN-1
T62815PRMT5-IN-1 hydrochloride
sc-59650PRMT5 (PRMT5-21)
T209477-01PRMT5/EGFR-IN-1
T205416-01PRMT5 ligand 1
527297-01PRMT5
MBS8503550-01PRMT5 Antibody
505990-01PRMT5 discontinued
TS423791P5PRMT5 CytoSection

Popular Products