Ac-ESMD-CHO

• UNSPSC Description:

  Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].

• Target Antigen:

  Casein Kinase

• Type:

  Peptides

• Related Pathways:

  Cell Cycle/DNA Damage;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ac-esmd-cho.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C[C@@H](C=O)NC([C@H](CCSC)NC([C@H](CO)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O

• Molecular Weight:

  506.53

• References & Citations:

  [1]Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.|[2]Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  191338-87-1